
Thioflavin T
CAS No. 2390-54-7
Thioflavin T ( Basic Yellow 1 )
产品货号. M22677 CAS No. 2390-54-7
硫磺素 T 是一种广泛用于可视化的染料,是一种阳离子苯并噻唑染料,在与组织切片中的淀粉样蛋白结合后显示出增强的荧光。硫磺素 T (ThT) 是一种苯并噻唑染料,在与淀粉样蛋白原纤维结合后显示出增强的荧光,通常用于离体和体外诊断淀粉样原纤维。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
1G | ¥235 | 有现货 |
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生物学信息
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产品名称Thioflavin T
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述硫磺素 T 是一种广泛用于可视化的染料,是一种阳离子苯并噻唑染料,在与组织切片中的淀粉样蛋白结合后显示出增强的荧光。硫磺素 T (ThT) 是一种苯并噻唑染料,在与淀粉样蛋白原纤维结合后显示出增强的荧光,通常用于离体和体外诊断淀粉样原纤维。
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产品描述Thioflavin T is a widely used dye for visualizing and is a cationic Benzothiazole dye that shows enhanced fluorescence upon binding to amyloid in tissue sections.Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission[1]. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.(In Vitro):Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission.
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体外实验——
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体内实验——
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同义词Basic Yellow 1
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number2390-54-7
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分子量318.86
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分子式C17H19ClN2S
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纯度>98% (HPLC)
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溶解度DMSO:21.5 mg/mL(67.43 mM);H2O:12.5 mg/mL (39.20 mM; Need ultrasonic)
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SMILES[Cl-].CN(C)c1ccc(cc1)-c1sc2cc(C)ccc2[n+]1C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Khurana R, et al. Mechanism of thioflavin T binding to amyloid fibrils. J Struct Biol. 2005 Sep;151(3):229-38.
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